Enzymes, Signaling Proteins, Extracellular Ligands, Signaling Reagents, Antibodies

Catalog No.	Pack Size	Price (USD)
P07-63R-100	100 ug	$595
P07-63R-BULK	BULK	Contact Us

Catalog No.

Pack Size

Price (USD)

P07-63R-100

100 ug

$595

P07-63R-BULK

BULK

Overview:

PAK7 (also known as PAK5) is a novel human PAK family kinase that contains a CDC42/Rac1 interactive binding (CRIB) motif at the N-terminus and a Ste20-like kinase domain at the C-terminus (1). The p21-activated kinase (PAK) family of protein kinases has recently attracted considerable attention as an effector of Rho family of small G proteins and as an upstream regulator of MAPK signalling pathways during cellular events such as re-arrangement of the cytoskeleton and apoptosis. PAK7 like the other Paks has been implicated in the regulation of cell morphology, motility and transformation.

References:

1. Pandey, A. et al: Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain. Oncogene. 2002 May 30;21(24):3939-48.

Specificity:

Recognizes the PAK7 protein

Cross Reactivity:

Human

Host / Isotype / Clone#:

Rabbit, IgG

Immunogen:

PAK7 antibody was raised against a 13 amino acid synthetic peptide from near the center of human PAK7

Purification:

Affinity chromatography

Stability:

Store at 4^oC (add 0.1% NaN₃) for several months, and at -20^oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data:

Western blot analysis of PAK7 in T24 lysate with PAK7 antibody at (A) 2 and (B) 4 ug/ml.