Rabbit Polyclonal Antibody
Catalog No. P38-63CR
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
P38-63CR-100 | 100 ug | $595 | |
P38-63CR-BULK | BULK | Contact Us |
Overview:
Mammalian PTPases can be subdivided into 1 of 2 broad categories: transmembrane receptor PTPases and intracellular PTPases. PTPN11 is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain (1). This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration (2)
References:
1. Dechert, U. et al: Protein-tyrosine phosphatase SH-PTP2 (PTPN11) is localized to 12q24.1-24.3. Hum. Genet. 96: 609-615, 1995.
2. Ahmad, S. et al: A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains. Proc. Nat. Acad. Sci. 90: 2197-2201, 1993.
Specificity:
Recognizes the PTPN11 protein
Cross Reactivity:
Human, Mouse and Rat
Host / Isotype / Clone#:
Rabbit, IgG
Immunogen:
PTPN11 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human PTPN11.
Purification:
Affinity chromatography
Stability:
Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data:
Western blot analysis of PTPN11 in mouse skeletal muscle tissue lysate with PTPN11 antibody at (A) 0.5 and (B) 1 ug/ml.
There are no related publications available for this product.
Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Neurobiology, Phosphatases
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