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CDK7/CyclinH1/MNAT1, Active

Recombinant full-length human CDK7, Cyclin H1 and MNATI were co-expressed by baculovirus in Sf9 insect cells using N-terminal His tags.
Catalog No. C36-10H


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Catalog No. Pack Size Price (USD)
C36-10H-05 5 ug $226
C36-10H-10 10 ug $325
C36-10H-BULK BULK Contact Us  


Overview:

CDK7 gene is a member of the cyclin-dependent protein kinase family that is important regulators of cell cycle progression (1). CDK7 forms a trimeric complex with cyclin H and MAT1, which functions as a CDK-activating kinase (CAK). CDK7 is an essential component of the transcription factor TFIIH that is involved in transcription initiation and DNA repair. CDK7 is thought to serve as a direct link between the regulation of transcription and the cell cycle (2).


Gene Aliases:

CDK7: CAK1, STK1, CDKN7, p39MO15 Cyclin H1: CCNH, CAK, p34, p37 MNATI: MAT1, RNF66


Genbank Number:


References:


1. Fisher, R. P.;A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell 78: 713-724, 1994.

2. Larochelle, S. Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Molec. Cell 25: 839-850, 2007.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~40kDa, Cyclin H1 ~39kDa, and MNAT1 ~37kDa



Product Datasheets



RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases


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