Overview:

CDC25A is a member of the CDC25 family of phosphatases and is required for cell cycle progression from G1 to S phase. CDC25A activates the cyclin-dependent kinases by removing two inhibitory phosphate groups on the CDKs. CDC25A is a potential oncogene since it promotes cell division. CDC25A is over-expressed in a number of cancers and functions as an androgen receptor (AR) co-regulator suppressing the AR transcriptional activity. Human cells respond to ultraviolet light or ionizing radiation by rapid, ubiquitin- and proteasome-dependent protein degradation of CDC25A (1).

References:

1. Falck, J. et al: The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410842-847, 2001.