Overview:

HDAC11 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. HDAC11 belongs to class IV of the histone deacetylase family that localizes to the nucleus and is involved in regulating the expression of interleukin 10 (1). HDAC11 expression is the highest in brain, heart, skeletal muscle, kidney and testis. HDAC11 control the DNA expression by modifying the core histone octamers that package DNA into dense chromatin structures and repress gene expression. HDAC11 has HDAC activity and this activity is inhibitable by trapoxin, an HDAC inhibitor (2). In coimmunoprecipitation experiments, HDAC11 interacts with HDA6.

References:

1. Villagra, A. et al: The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance. Nat Immunol. 2009 Jan;10(1):92-100.

2. Gao, L. et.al: Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. J. Biol. Chem. 277: 25748-25755, 2002.