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SOD2 Protein

Recombinant full-length human SOD2 was expressed in E. coli cells using an N-terminal GST tag
Catalog No. S27-30G


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Catalog No. Pack Size Price (USD)
S27-30G-50 50 ug $435
S27-30G-20 20 ug $215
S27-30G-BULK BULK Contact Us  


Overview:

SOD2 (superoxide dismutase 2) is a member of the iron/manganese superoxide dismutase family. SOD2 binds to the superoxide byproducts of the mitochondrial electron transport chain and converts them to hydrogen peroxide and diatomic oxygen. Failure of SOD2 to remove the superoxide byproducts leads to an increase in mitochondrial reactive oxygen species resulting in biochemical aberrations with features reminiscent of mitochondrial myopathy, Friedreich ataxia, and HMGCL deficiency (1). Mutations in SOD2 have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer (2).


Gene Aliases:

Mn-SOD, MNSOD, IPO-B, Superoxide Dismutase 2


Genbank Number:


References:


1. Melov, S. et al: A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase. Nature Genet. 18: 159-163, 1998.

2. Hiroi, S. et al: Polymorphisms in the SOD2 and HLA-DRB1 genes are associated with nonfamilial idiopathic dilated cardiomyopathy in Japanese. Biochem. Biophys. Res. Commun. 261: 332-339, 1999.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~51 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cellular Stress, Inflammation, Neurobiology


RELATED PRODUCTS


  SOD1 Protein, S26-30G

  HO1 Protein, H20-30G

  SOD3 Protein, S28-31G


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