VEGFRK inhibitor
Catalog No. F11-900D
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| F11-900D-10 | 10 mg | $75 | |
| F11-900D-50 | 50 mg | $300 | |
| F11-900D-BULK | BULK | Contact Us |
Overview:
Potent, selective inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC50 = 77 nM) and VEGFR-2 (FLK-1/KDR, IC50 = 37 nM) (1). Weaker inhibitor of other tyrosine kinases including PDGFR-beta (IC50 = 580 nM), c-KIT (IC50 = 730 nM), FLT-4 (IC50 = 660 nM) and c-FMS (IC50 = 1.4 uM). Inactive against the EGFR, c-SRC, v-ABL, and protein kinase Calpha (IC50 > 10 uM). Inhibits the growth of multiple myeloma cells in the bone marrow microenvironment2.
References:
1. J.M. Wood et al. Cancer Res. 2000 60:2178
2. B. Lin et al. Cancer Res. 2002 62:5019
CAS Registry Number:
212141-51-0
Molecular Formula:
C20H15CIN4•2HCl
Appearance:
White to off-white powder
Melting Point:
N/A
Molecular Weight:
419.7
Purity:
>98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (20 mg/ml, warm); or water (100 mg/ml)
Aliases:
1. N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine dihydrochloride
2. CGP-79787
3. PTK-787
4. ZK222584
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.
There are no related publications available for this product.
Angiogenesis, Cancer, Cell Cycle, Neurobiology
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