Overview:

HtrA (also designated as DegP) is a trypsin-like serine protease which contains PDZ domain and involves in heat-shock response, chaperone function, and apoptosis (1). HtrA is an error sensor that specifically represses genetic competence when the overall level of biosynthetic errors in cellular proteins is low (2).

Gene Aliases:

SPN23F22720

Genbank Number:

B8ZQD0

References:

1. Ge X. et.al: DegP primarily functions as a protease for the biogenesis of β-barrel outer membrane proteins in the Gram-negative bacterium Escherichia coli. FEBS J. 2013 Dec 26. doi: 10.1111/febs.12701.

2. Cassone M. et.al: The HtrA protease from Streptococcus pneumoniae digests both denatured proteins and the competence-stimulating peptide. J Biol Chem. 2012 Nov 9;287(46):38449-59.