Full-length recombinant human HDAC1 was expressed by baculovirus in Sf9 insect cells using a C-terminal GST tag.
Catalog No. H83-30G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| H83-30G-05 | 5 ug | $226 | |
| H83-30G-10 | 10 ug | $325 | |
| H83-30G-100 | 100 ug | $1825 | |
| H83-30G-BULK | BULK | Contact Us |
Overview:
HDAC1 or Histone deacetylase 1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex which plays a key role in the regulation of eukaryotic gene expression (1). HDAC1 interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis. HDAC1 is an essential element of the co-activation system for IFN-induced gene regulation and antiviral responses (2).
Gene Aliases:
HD1, RPD3, GON-10, RPD3L1, DKFZp686H12203
Genbank Number:
References:
1. Bauer, W. R. et.al : Nucleosome structural changes due to acetylation. J. Molec. Biol. 236: 685-690, 1994.
2. Nusinzon, I. et.al : Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1. Proc. Nat. Acad. Sci. 100: 14742-14747, 2003.
Specific Activity:
Sample Histone Deacetylase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~81 kDa
MB Robers et al., Target engagement and drug residence time can be observed in living cells with BRET Nature Communications December 2015 10.1038/ncomms10091
Jaskula-Sztul Renata et al., Tumor suppressor role of Notch3 in Medullary Thyroid Carcinoma revealed by genetic and pharmacological induction Molecular Cancer Therapeutics November 2014 10.1158/1535-7163.MCT-14-0073
Hou Xuben et al., Enhancing the Sensitivity of Pharmacophore-Based Virtual Screening by Incorporating Customized ZBG Features: A Case Study Using Histone Deacetylase 8 Journal of Chemical Information and Modeling March 2015 10.1021/ci500762z
S Jang et al., Novel analogs targeting histone deacetylase suppress aggressive thyroid cancer cell growth and induce re-differentiation. Cancer Gene Therapy August 2015 10.1038/cgt.2015.37
et al., Identification of Highly Selective and Potent Histone Deacetylase 3 Inhibitors Using Click Chemistry-Based Combinatorial Fragment Assembly PLoS ONE July 2013
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