Overview:

PI3K (p120 gamma) is a member of the PI3K family that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. PI3K (p120 gamma) is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, PI3K (p120 gamma) is thought to play a pivotal role in the regulation of cytotoxicity in NK cells (1). In addition, PI3K (p120 gamma) plays an inhibitory role in inflammatory mediator-induced human vascular smooth muscle cell calcification through regulating alkaline phosphatase expression (2).

Gene Aliases:

p110 gamma: PI3K, PIK3, PI3CG, PI3Kgamma, PIK3CG

Genbank Number:

NM_002649

References:

1. Jiang, K. et al: Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells. Nature Immun. 1: 419-425, 2000.

2. Patrucco, E.et al: PI3K-gamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects. Cell 118: 375-387, 2004.