Overview:

Receptor-type tyrosine-protein phosphatase eta or protein-tyrosine phosphatase receptor type J (R-PTP-J or CD148) are membrane protein tyrosine phosphatase initially identified on the membrane of HeLa and F-36P human leukemic cells. It contains an extracellular portion compromised of eight fibronectin III domains, a transmembrane segment and an intracytoplasmic tail which contains a single PTP domain. The presence of fibronectin III motifs in the extracellular domain suggest its possible involvement in cell adhesion processes.

Gene Aliases:

CD148; DEP1; HPTPeta; R-PTP-ETA; SCC1

Genbank Number:

NM_002843

References:

1. Ostman, A., et al: Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density. Proc Natl Acad Sci USA, 91. 9680-9684, 1994.

2. Honda, H., et al: Molecular cloning, characterization and chromosomal localization of a novel protein-tyrosine phosphatase, HPTPn. Blood, 84. 4186-4194, 1994.

3. Gayà A, et al: CD148, a new membrane tyrosine phosphatase involved in leukocyte