Overview:

IRR or insulin receptor-related receptor is a tyrosine protein kinase that is required for the appearance of male gonads and thus for male sexual differentiation (1). The expression of IRR mRNA is restricted to a few tissue types and has been detected in neuronal tissues as well as in neuroblastomas. As a result of its occurrence in neuroblastomas, it has speculated that IRR may be involved in tumor genesis. RT-PCR and solution hybridization/RNAse protection assay have shown strong coupling of IRR mRNA in 18 tumor cell lines (2).

Gene Aliases:

INSRR

Genbank Number:

NM_014215

References:

1. Zhang, B. and Roth, R.A. The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities. J. Biol. Chem. 1992; 267 (26): 18320-8.

2. Elmlinger, M.W. et al: Correlation of type I insulin-like growth factor receptor (IGF-I-R) and insulin receptor-related receptor (IRR) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin. Regul. Pept., 1999; 84 (1-3): 37-42.