EGFR inhibitor
Catalog No. E10-900
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| E10-900-200 | 250 mg | $90 | |
| E10-900-1000 | 1 g | $270 | |
| E10-900-BULK | BULK | Contact Us |
Overview:
Potent and selective EGFR kinase inhibitor (IC50 = 23-79 nM) (1). Inhibits EGFR autophosphorylation and inhibits tumor growth in vivo (2). Enhances efficacy of cytotoxic agents (3). Inhibits growth factor production and angiogenesis (4). Clinically useful anticancer agent.
References:
1. J Baselga et al. Drugs 2000 60:33, Suppl. 1
2. D McKillop et al. Mol. Cancer Ther. 2005 4:641
3. FM Sirotnak et al. Clin. Cancer Res. 2000 6:4885
4. F Ciaradiello et al. Clin. Cancer Res. 2001 7:1459
CAS Registry Number:
184475-35-2
Molecular Formula:
C22H24ClFN4O3
Appearance:
Tan solid
Melting Point:
N/A
Molecular Weight:
446.9
Purity:
>98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (40 mg/ml) or ethanol (4 mg/ml)
Aliases:
1. N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy) quinazolin-4-amine;
2. ZD1839
Storage and Stability:
Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 1 month.
Molecular Structure:
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There are no related publications available for this product.
AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, PKA/PKC Pathway, Receptor Tyrosine Kinases
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