Recombinant human KSR2 (554-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. K08-15G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| K08-15G-20 | 20 ug | $215 | |
| K08-15G-50 | 50 ug | $435 | |
| K08-15G-BULK | BULK | Contact Us |
Overview:
KSR2 or kinase suppressor of Ras 2 specifically regulates the activity of MEKK3 and COT but not other members of the MAP3K family (1). KSR interacts with a regulatory Raf molecule in cis to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf molecule in trans (2).
Gene Aliases:
None
Genbank Number:
References:
1. Brennan, D. F.et.al: A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK. Nature 472: 366-369, 2011.
2. Channavajhala, P. L. et.al: hKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappa-B pathways in inflammation. Biochem. Biophys. Res. Commun. 334: 1214-1218, 2005.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
72 kDa
There are no related publications available for this product.
Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases
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