Recombinant full-length human CK2alpha1 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. C70-10G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| C70-10G-05 | 5 ug | $226 | |
| C70-10G-10 | 10 ug | $325 | |
| C70-10G-BULK | BULK | Contact Us |
Overview:
CK2α is a serine-threonine protein kinase whose targets include many critical regulators of cellular growth. It is highly expressed in a lymphopro-liferative disease of cattle and in many human cancers. Overexpression of the CK2 catalytic subunit in lymphocytes of transgenic mice leads to T cell lymphoma (1). The highest CK2α1 activity is found in mouse testicles and brain, followed by spleen, liver, lung, kidney and heart (2).
Gene Aliases:
CKII; CK2A1; CKIIα; CSNK2A1
Genbank Number:
References:
1. Rifkin, IR. et al: Acceleration of lymphoproliferative and autoimmune disease by transgenic protein kinase CK2 alpha. J Immunol. 1998 Nov 15;161(10):5164-70.
2. Guerra B. et al: Protein kinase CK2: evidence for a protein kinase CK2beta subunit fraction, devoid of the catalytic CK2alpha subunit, in mouse brain and testicles. FEBS Lett. 1999 Dec 3;462(3):353-7.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~70 kDa
Wang L et al., An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function Molecular Psychiatry January 2019 10.1038/s41380-018-0324-x
Sager RA et al., Post-translational regulation of FNIP1 creates a rheostat for the molecular chaperone Hsp90
Cell reports January 2019 10.1016/j.celrep.2019.01.018
I. Dobrikov Mikhail et al., Dynamic Regulation of the Translation Initiation Helicase Complex by Mitogenic Signal Transduction to Eukaryotic Translation Initiation Factor 4G Molecular and Cellular Biology March 2013 10.1128/MCB.01441-12
Rimana Sarah et al., Phosphorylation of the Transcription Factor YY1 by CK2α Prevents Cleavage by Caspase 7 during Apoptosis Molecular and Cellular Biology February 2012 10.1128/MCB.06466-11
Gagne Philippe Jean et al., Proteomic Investigation of Phosphorylation Sites in Poly(ADP-ribose) Polymerase-1 and Poly(ADP-ribose) Glycohydrolase Journal of Proteome Research February 2009 10.1021/pr800810n
Cancer, Inflammation, Neurobiology, NfkB Pathway, Ser/Thr Kinases, WNT Signaling
Kinase Assay Buffer I, K01-09
CK1 delta, Active, C65-10G
CK2 alpha 2, Active, C71-10G
CK1 gamma 1, Active, C68-11G
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