MLK2, Active
Recombinant human MLK2 (1-446) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M18-11G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| M18-11G-05 | 5 ug | $226 | |
| M18-11G-10 | 10 ug | $325 | |
| M18-11G-BULK | BULK | Contact Us |
Recombinant human MLK2 (1-446) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M18-11G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| M18-11G-05 | 5 ug | $226 | |
| M18-11G-10 | 10 ug | $325 | |
| M18-11G-BULK | BULK | Contact Us |
Overview:
MLK2 or mixed-lineage kinase 2 is a member of the serine/threonine kinase family, which activates MAPK8 JNK and MKK4/SEK1. MLK2 itself can be phoshorylated, and activated by JNK kinases. MLK2 is also known as mitogen-activated protein kinase kinase kinase 10 (MAP3K10). MLK2 functions preferentially on the JNK signaling pathway which is involved in nerve growth factor (NGF) induced neuronal apoptosis. MLK2 was isolated as a cDNA fragment from MKN28 gastric cancer cell library using degenerate PCR (1). MLK2 is highly expressed in brain, skeletal muscle, and testis (2).
Gene Aliases:
MAP3K10, MST
Genbank Number:
References:
1. Katoh, M. et.al: Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain. Oncogene 10: 1447-1451, 1995.
2. Dorow, D. S. et.al: complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2. Europ. J. Biochem. 234: 492-500, 1995.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~76 kDa
Natsuo Takeda Armelle et al., Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1 EMBO Journal August 2014 10.15252/embj.201487808
et al., Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants. Cancer cell February 2020
Apoptosis/Autophagy, Cell Cycle, JNK/SAPK Pathway, Ser/Thr Kinases
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