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HIPK4, Active

Recombinant full-length human HIPK4 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. H06-10G


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Catalog No. Pack Size Price (USD)
H06-10G-05 5 ug $226
H06-10G-10 10 ug $325
H06-10G-BULK BULK Contact Us  


Overview:

HIPK4 or homeodomain interacting protein kinase 4 is a serine/threonine protein kinase that can act as a co-repressor of transcription factors (1). HIPK4 has been shown to phosphorylate the human p53 protein at serine 9, both in vitro and in vivo which is important for p53 mediated transcriptional repression. RT-PCR analysis showed moderate expression of HIPK4 in lung and white adipose tissue and weak expression in brain and liver. HIPK4 expression has also been observed in various cancer cell lines (2).


Gene Aliases:

FLJ32818


Genbank Number:


References:


1. Arai, S. et al: Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9. FEBS Lett. 2007;11;581(29):5649-57.

2. Di Stefano, V. et al: Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis. Exp. Cell. Res. 2004;15;293(2):311-20.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~110 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Metabolic Disorder, Ser/Thr Kinases, WNT Signaling


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