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SIK, Active

Recombinant human SIK (1-303) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. S14-11BH


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Catalog No. Pack Size Price (USD)
S14-11BH-05 5 ug $226
S14-11BH-10 10 ug $325
S14-11BH-BULK BULK Contact Us  


Overview:

SIK is a protein kinase that is involved in regulating AMPK-related kinases (1). SIK may mediate the physiological effects of LKB1, including its tumour suppressor function. SIK is also involved in signaling by various proteins like STRAD, NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK that are related to AMPK. Activation of SIK1 by phosphorylation on thr322 can lead to an increase in the catalytic activity of sodium/potassium ATPase alpha subunit at the plasma membrane (2). This results in an increase in intracellular sodium in intact mammalian cells.


Gene Aliases:

SNF1LK, MSK, SIK1


Genbank Number:


References:


1. Takemori, H. Et al: TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain. FEBS J. 2007; 274 (13): 3202–9. 

2. Sjostrom, M.; SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process. Proc. Nat. Acad. Sci. 104: 16922-16927, 2007.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

36~39 kDa



Product Datasheets



RESEARCH AREAS

Cancer, Ser/Thr Kinases


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