Overview:

PTPRM is a member of the protein tyrosine phosphatase family and can participate in a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation (1). PTPRM has been shown to mediate cell-cell aggregation through the interaction with another molecule of PTPRM on an adjacent cell. PTPRM can interact with scaffolding protein RACK1/GNB2L1 and this interaction may be necessary for downstream signaling in response to cell-cell adhesion (2). PTPRM has been shown to be expressed in human pulmonary vascular endothelia where it directly binds to VE-cadherin and regulates both the tyrosine phosphorylation state of VE-cadherin and barrier integrity.

Gene Aliases:

RPTPM, RPTPU, PTPRL1, hR-PTPu, R-PTP-MU

Genbank Number:

BC051651

References:

1. Phillips-Mason, P.J. et al: The receptor protein-tyrosine phosphatase PTPmu interacts with IQGAP1. J. Biol. Chem. 2006; 281(8):4903-10.

2. Koop, E.A. et al: Receptor protein tyrosine phosphatase mu expession as a marker for endothelial cell heterogeneity; analysis of RPTPmu gene expression using LacZ knock-in mice. Int. J. Dev. Biol. 2003; 47(5):345-54