Overview:

PTPRA (also known as LRP) is a member of the protein tyrosine phosphatase family and contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. PTPRA dephosphorylates SRC family kinases, potassium channels and NMDA receptors and exists as three alternatively spliced variants which encode two distinct isoforms (1). Absence of PTPRA compromises correct positioning of pyramidal neurons during development of mouse hippocampus (2).

Gene Aliases:

LRP, HLPR, PTPA, HEPTP, HPTPA, RPTPA, PTPRL2, HPTPalpha, R-PTP-alpha

Genbank Number:

NM_002836

References:

1. Matthews, R J. et al: Identification of an additional member of the protein-tyrosine-phosphatase family: evidence for alternative splicing in the tyrosine phosphatase domain. Proc. Nat. Acad. Sci. 87: 4444-4448, 1990.

2. Petrone, A. et al: Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation. EMBO J. 2003 Aug 15;22(16):4121-31.