Recombinant human PCTK1 (CDK16) (107-end) and Cyclin Y (2-end) were co-expressed by baculovirus in Sf9 insect cells using N-terminal GST tags.
Catalog No. P09-11G
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PCTK1 or PCTAIRE PROTEIN KINASE 1 belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. PCTK1 plays a role in signal transduction cascades in terminally differentiated cells, in exocytosis, and in transport of secretory cargo from the endoplasmic reticulum (1). PCTK1 is ubiquitously expressed with the highest levels detected in the brain and testis. PCTK1 also contained the gene coding for ubiquitin-activating enzyme UBE1 that previously shown to mapped to Xp11.3 (2).
PCTK1 (CDK16): FLJ16665; PCTAIRE; PCTAIRE1; PCTGAIRE CyclinY: CCNY; C10orf9; CBCP1; CCNX; CFP1
1. Meyerson, M. et.al: A family of human cdc2-related protein kinases. EMBO J. 11: 2909-2917, 1992.
2. Knight, J. C. et.al: Physical linkage of the cdc2-related gene (PCTK1) and the ubiquitin-activating enzyme E1 gene (UBE1) on human Xp11.3. Cytogenet. Cell Genet. 71: 155-157, 1995.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
PCTK1 (CDK16) ~ 66kDa and Cyclin Y~ 64kDa
M Kanke et al., Cohesin acetylation and Wapl-Pds5 oppositely regulate translocation of cohesin along DNA. EMBO Journal November 2016 10.15252/embj.201695756
Bhandaria Deepali et al., Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration?proliferation dichotomy PNAS July 2015 10.1073/pnas.1514157112
Cancer, Cell Cycle, Ser/Thr Kinases