Recombinant human MRCKalpha (1-473) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C27-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
C27-11G-05 | 5 ug | $226 | |
C27-11G-10 | 10 ug | $325 | |
C27-11G-BULK | BULK | Contact Us |
Overview:
Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase α (MRCKα) is a Cdc42/Rac/Rho interactive/binding serine/threonine kinase with multiple functional domains (1). MRCK are effectors of RhoA and Cdc42, respectively, for actin reorganization. MRCKα is a critical regulator of signal transduction pathways in eukaryotic cells that are known principally for their role in regulating the cytoskeleton, and they do so by recruiting a variety of downstream effector proteins (2).
Gene Aliases:
CDC42BPA, MRCK, PK428, FLJ23347, KIAA0451, DKFZp686L1738, DKFZp686P1738
Genbank Number:
References:
1. Ivan, T. et al: Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase α reveals multiple alternative splicing and functional diversity. Gene; 2003; 304:107-115.
2. Ivan, T. et al: Phosphorylation of a Novel Myosin Binding Subunit of Protein Phosphatase 1 Reveals a Conserved Mechanism in the Regulation of Actin Cytoskeleton. J. Biol. Chem., 2001: 276 (24): 21209-21216.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~73 kDa
There are no related publications available for this product.
Angiogenesis, Cancer, Invasion/Metastasis, Ser/Thr Kinases
STAY CONNECTED
Fax: 1-604-232-4601