STK19 is a member of the serine/threonine kinase family that shows a manganese-dependent protein kinase activity and phosphorylates α-casein at ser/thr residues and histone at ser residues. STK19 contains a positively charged putative nuclear localization signal, multiple potential phosphorylation sites, 2 amidation sites, 9 potential N-myristoylation sites, and no N-glycosylation sites. STK19 has been shown to localize predominantly in the nucleus (1). The phosphorylation of STK19 is thought to be involved in transcriptional regulation. STK19 localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 (2).
D6S60; D6S60E; G11; HLA-RP1; RP1
1. Gomez-Escobar, N. et.al: The G11 gene located in the major histocompatibility complex encodes a novel nuclear serine/threonine protein kinase. J. Biol. Chem. 273: 30954-30960, 1998.
2. Shen, L. et.al: Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region: molecular cloning, exon-intron structure, composite retroposon, and breakpoint gene duplication. J. Biol. Chem. 269: 8466-8476, 1994.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, Ser/Thr Kinases