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AXIN1 Protein

Full-length recombinant human AXIN1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. A71-30G


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Catalog No. Pack Size Price (USD)
A71-30G-20 20 ug $314
A71-30G-50 50 ug $545
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Overview:

AXIN 1 encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain that interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. AXIN1 has both positive and negative regulatory roles in Wnt-beta-catenin signaling. AXIN1 is a core component of a 'destruction complex' that promotes phosphorylation and polyubiquitination of cytoplasmic beta-catenin, resulting in beta-catenin proteasomal degradation in the absence of Wnt signaling. Nuclear accumulation of AXIN1 can positively influence beta-catenin-mediated transcription during Wnt signalling and can induce apoptosis (1). AXIN1 may be an effective therapeutic molecule for suppressing growth of hepatocellular and colorectal cancers (2).


Gene Aliases:

AXIN; MGC52315


Genbank Number:


References:


1. Lui, T. T. H.et.al: The ubiquitin-specific protease USP34 regulates axin stability and Wnt/beta-catenin signaling. Molec. Cell. Biol. 31: 2053-2065, 2011.

2. Satoh, S.et.al: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nature Genet. 24: 245-250, 2000.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~135 kDa



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cell Cycle, JNK/SAPK Pathway, WNT Signaling


RELATED PRODUCTS


  AXIN2 Protein, A72-30G


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