AXIN 1 encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain that interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. AXIN1 has both positive and negative regulatory roles in Wnt-beta-catenin signaling. AXIN1 is a core component of a 'destruction complex' that promotes phosphorylation and polyubiquitination of cytoplasmic beta-catenin, resulting in beta-catenin proteasomal degradation in the absence of Wnt signaling. Nuclear accumulation of AXIN1 can positively influence beta-catenin-mediated transcription during Wnt signalling and can induce apoptosis (1). AXIN1 may be an effective therapeutic molecule for suppressing growth of hepatocellular and colorectal cancers (2).
1. Lui, T. T. H.et.al: The ubiquitin-specific protease USP34 regulates axin stability and Wnt/beta-catenin signaling. Molec. Cell. Biol. 31: 2053-2065, 2011.
2. Satoh, S.et.al: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nature Genet. 24: 245-250, 2000.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Apoptosis/Autophagy, Cancer, Cell Cycle, JNK/SAPK Pathway, WNT Signaling