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AXIN2 Protein

Full-length recombinant human AXIN2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. A72-30G


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Catalog No. Pack Size Price (USD)
A72-30G-20 20 ug $314
A72-30G-50 50 ug $545
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Overview:

AXIN2 plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway and Axin2-expressing cells themselves produce Wnt signals as well as long-range secreted Wnt inhibitors, suggesting an autocrine mechanism of stem cell self-renewal (1). AXIN2 is highly expressed in thymus, prostate, testis, ovary, and small intestine.The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. AXIN2 as a gene that is responsible for hereditary colorectal cancer and tooth agenesis that may be an indicator of cancer susceptibility (2).


Gene Aliases:

AXIL


Genbank Number:


References:


1. Lim, X.et.al: Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling. Science 342: 1226-1230, 2013.

2. Lammi, L.et.al: Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. Am. J. Hum. Genet. 74: 1043-1050, 2004.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~130 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cell Cycle, JNK/SAPK Pathway, WNT Signaling


RELATED PRODUCTS


  AXIN1 Protein, A71-30G


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