AXIN2 plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway and Axin2-expressing cells themselves produce Wnt signals as well as long-range secreted Wnt inhibitors, suggesting an autocrine mechanism of stem cell self-renewal (1). AXIN2 is highly expressed in thymus, prostate, testis, ovary, and small intestine.The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. AXIN2 as a gene that is responsible for hereditary colorectal cancer and tooth agenesis that may be an indicator of cancer susceptibility (2).
1. Lim, X.et.al: Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling. Science 342: 1226-1230, 2013.
2. Lammi, L.et.al: Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. Am. J. Hum. Genet. 74: 1043-1050, 2004.
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Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Apoptosis/Autophagy, Cancer, Cell Cycle, JNK/SAPK Pathway, WNT Signaling