AMHR2 is a serine/threonine kinase with a single transmembrane domain belonging to the family of type II receptors for TGF-beta-related proteins which bind the ligand on their own but require the presence of a type I receptor for signal transduction. AMHR2 encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone which results in male sex differentiation and produced in the testes by different cells and has different effects (1). AMHR2 may be a regulator of neuronal pathways which vary in the male population and underlie subtle sex-linked biases (2).
AMHR; MISR2; MISRII; MRII
1. Imbeaud, S. et.al: Insensitivity to anti-mullerian hormone due to a mutation in the human anti-mullerian hormone receptor. Nature Genet. 11: 382-388, 1995.
2. Wang, P.-Y. et.al: Mullerian inhibiting substance contributes to sex-linked biases in the brain and behavior. Proc. Nat. Acad. Sci. 106: 7203-7208, 2009.
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Cancer, Ser/Thr Kinases