NPR1 or natriuretic peptide receptor 1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (1). NPR1 expression influences blood pressures of mice in a dose-dependent manner. ANP and NPR1 binding induces an increase in intracellular cGMP which initiates natriuresis, diuresis, and vasodilation, all of which contribute to lowering blood pressure. Low Npr1 expression leads to a salt-sensitive increase in BP, whereas high Npr1 expression lowers BP and protects against high dietary salt (2).
ANPa, GUC2A, GUCY2A
1. Garbers, D. L.et.al: Guanylyl cyclase receptors. J. Biol. Chem. 269: 30741-30744, 1994.
2. Oliver, P. M.et.al: Natriuretic peptide receptor 1 expression influences blood pressures of mice in a dose-dependent manner. Proc. Nat. Acad. Sci. 95: 2547-2551, 1998.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
There are no related publications available for this product.
Cardiovascular Disease, Cellular Stress, Neurobiology, Ser/Thr Kinases