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POMK (SGK196) Protein

Full-length recombinant human POMK (SGK196) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S55-34G


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Catalog No. Pack Size Price (USD)
S55-34G-20 20 ug $215
S55-34G-50 50 ug $435
S55-34G-BULK BULK Contact Us  


Overview:

POMK or protein-O-mannose kinase encodes a protein that may be involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (a-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleton. POMK is involved in cell surface presentation of laminin -binding carbohydrates on alpha-dystroglycan (1). Mutations in GTDC2, B3GALNT2, and SGK196 disrupt dystroglycan receptor function and lead to congenital muscular dystrophy (2).


Gene Aliases:

MDDGA12; SGK196


Genbank Number:


References:


1. Jae, L. T.et.al: Deciphering the glycosylome of dystroglycanopathies using haploid screens for Lassa virus entry. Science 340: 479-483, 2013.

2. Yoshida-Moriguchi, T. et.al: SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function. Science 341: 896-899, 2013.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

68 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Metabolic Disorder, Neurobiology


RELATED PRODUCTS


  SGK1, Unactive, S06-14G


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