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EIF4E Protein

Recombinant full-length human EIF4E was expressed in E. coli cells using a N-terminal GST tag.
Catalog No. E34-30G


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Catalog No. Pack Size Price (USD)
E34-30G-50 50 ug $435
E34-30G-20 20 ug $215
E34-30G-BULK BULK Contact Us  


Overview:

Eukaryotic Translation Initiation Factor 4E (EIF4E), plays a role in translation initiation where it binds the 5 m7G cap found on mRNAs. EIF4E governs cell cycle progression and cellular proliferation by coordinately the expression of several genes at the post-transcriptional level. EIF4E functions as a central node of an RNA regulon, which plays an essential role in normal differentiation and development (1). The significant association of EIF4E with VEGF and cyclin D1 in multiple tumors supports a role for EIF4E in translational regulation of proteins related to angiogenesis and growth. The overexpression of EIF4E is involved in the malignant progression of human breast cancer (2).


Gene Aliases:

CBP


Genbank Number:


References:


1. Culjkovic, B. et al: Controlling gene expression through RNA regulons: the role of the eukaryotic translation initiation factor eIF4E. Cell Cycle. 2007; 6(1):65-9.

2. Zhou, S. et al: Eukaryotic initiation factor 4E (eIF4E) and angiogenesis: prognostic markers for breast cancer. BMC Cancer. 2006; 30 (6): 231


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~51 kDa



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Inflammation, Neurobiology


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