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Rb (N-Term) Protein

Recombinant human Rb (48-378) was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. R05-56G


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Catalog No. Pack Size Price (USD)
R05-56G-50 50 ug $435
R05-56G-20 20 ug $215
R05-56G-BULK BULK Contact Us  


Overview:

Rb is the retinoblastoma gene product and was the first tumor suppressor cloned. Rb is a negative regulator of the cell cycle through its ability to bind the transcription factor E2F and repress transcription of genes required for S phase (1). Rb can bind to MDM2 and this overcomes both the antiapoptotic function of MDM2 and the MDM2-dependent degradation of p53. Rb associates with the Polycomb group (PcG) proteins to form a repressor complex that blocks entry of cells into mitosis (2). Rb colocalizes with nuclear PcG complexes and is important for association of PcG complexes with nuclear targets.


Gene Aliases:

RB1, OSRC


Genbank Number:


References:


1. Hanahan, D.et al: The hallmarks of cancer. Cell 100: 57-70, 2000.

2. Dahiya, A. et al: Linking the Rb and Polycomb pathways. Molec. Cell 8: 557-568, 2001.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~62 kDa



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Neurobiology


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