Growth-associated protein 43 (GAP-43, also known as neuromodulin and B-50) mediates axonal growth, branching, and pathfinding during development. Plays a pivotal role both during development and in axonal remodeling in the adult brain. Increased expression observed in pathological or traumatic lesions induces neuronal rewiring.
1. Grasselli G, et al: Structural plasticity of climbing fibers and the growth-associated protein GAP-43. Front Neural Circuits. 2013 Feb 21;7:25.
2. Oestreicher A. B., et al: (1997). B-50, the growth associated protein-43: modulation of cell morphology and communication in the nervous system. Prog. Neurobiol. 53, 627–686.
3. Buffo A., et al: (2003). Extrinsic regulation of injury/growth-related gene expression in the inferior olive of the adult rat. Eur. J. Neurosci. 18, 2146–2158
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
There are no related publications available for this product.