PPP2R1A or the PR65 subunit of protein phosphatase 2A (PP2A) acts as a scaffolding protein to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit, together forming the core of heterodimeric PP2A. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.
MRD36; PP2A-Aalpha; PP2AAALPHA; PR65A
1. Tang Z, et al: PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. Dev Cell. 10(5):575-85, 2006.
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Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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