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MO25α Protein

Recombinant full-length human MO25α was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. M51-30H


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Catalog No. Pack Size Price (USD)
M51-30H-20 20 ug $215
M51-30H-50 50 ug $435
M51-30H-BULK BULK Contact Us  


Overview:

MO25α (mouse protein 25 alpha) is a 40-kDa protein that interacts with the STE20-related adaptor-alpha (STRADα) pseudo kinase to form a regulatory complex capable of stimulating the activity of the LKB1 tumor suppressor protein kinase (1). LKB1 plays a critical role in cell proliferation, polarity and energy metabolism. LKB1 is mutated in the inherited Peutz-Jeghers cancer syndrome (PJS). MO25α binds directly to a conserved Trp-Glu-Phe sequence at the STRADαC terminus, and markedly enhances the binding of STRADα to LKB1 thereby increasing LKB1 catalytic activity (2).


Gene Aliases:

CAB39, CGI-66, FLJ22682


Genbank Number:


References:


1. Boudeau, J. et al: Analysis of the LKB1-STRAD-MO25 complex. J Cell Sci. 2004;117(Pt 26):6365-75.

2. Milburn, C.C. et al: Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor. Nat. Struct. Mol. Biol. 2004;11(2):193-200.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

63 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cardiovascular Disease, Metabolic Disorder


RELATED PRODUCTS


  MO25 alpha Protein, M51-30G

  MO25alpha siRNA Set I, M51-911B


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