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PTPRM (PTP- mu) Protein

Recombinant human PTPRM (764-1452) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P58-35G


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Catalog No. Pack Size Price (USD)
P58-35G-20 20 ug $215
P58-35G-50 50 ug $435
P58-35G-BULK BULK Contact Us  


Overview:

PTPRM is a member of the protein tyrosine phosphatase family and can participate in a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation (1). PTPRM has been shown to mediate cell-cell aggregation through the interaction with another molecule of PTPRM on an adjacent cell. PTPRM can interact with scaffolding protein RACK1/GNB2L1 and this interaction may be necessary for downstream signaling in response to cell-cell adhesion (2). PTPRM has been shown to be expressed in human pulmonary vascular endothelia where it directly binds to VE-cadherin and regulates both the tyrosine phosphorylation state of VE-cadherin and barrier integrity.


Gene Aliases:

RPTPM, RPTPU, PTPRL1, hR-PTPu, R-PTP-MU


Genbank Number:


References:


1. Phillips-Mason, P.J. et al: The receptor protein-tyrosine phosphatase PTPmu interacts with IQGAP1. J. Biol. Chem. 2006; 281(8):4903-10.

2. Koop, E.A. et al: Receptor protein tyrosine phosphatase mu expession as a marker for endothelial cell heterogeneity; analysis of RPTPmu gene expression using LacZ knock-in mice. Int. J. Dev. Biol. 2003; 47(5):345-54


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~110 kDa



Product Datasheets



RESEARCH AREAS

Cardiovascular Disease, Neurobiology, Phosphatases


RELATED PRODUCTS


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  PTPN1 (PTP1B), Active, P28-20G

  PTPRF (LAR), Active, P53-21G


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