HTRA4 is a serine protease with a conserved trypsin domain and a PDZ domain. As other related family members, HTRA4 may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. HrtA4 may contribute to shallow trophoblast invasion in preeclampsia (1) and imply a potential application as a biomarker for this disorder (2).
1. Wang LJ. et.al: High-temperature requirement protein A4 (HtrA4) suppresses the fusogenic activity of syncytin-1 and promotes trophoblast invasion. Mol Cell Biol. 2012 Sep;32(18):3707-17.
2. Inagaki A. et.al: Upregulation of HtrA4 in the placentas of patients with severe pre-eclampsia. Placenta. 2012 Nov;33(11):919-26.
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Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Cell Cycle, Neurobiology, Ser/Thr Kinases