Home   >    Proteins   >   Signaling Proteins

4EBP1 Protein

Recombinant full-length human 4EBP1 was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. E35-54G


Shop Online



Catalog No. Pack Size Price (USD)
E35-54G-50 50 ug $435
E35-54G-20 20 ug $215
E35-54G-BULK BULK Contact Us  


Overview:

4EBP1 is a member of a family of translation repressor proteins that directly interact with eukaryotic translation initiation factor 4E (EIF4E). Interaction of 4EBP1 with EIF4E inhibits the multi-subunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs thereby leading to repression of translation. Insulin treatment of adipose cells increases the phosphorylation of 4EBP1 and leads to reduced interaction of 4EBP1 with EIF4E (1). 4EBP1 is expressed in most tissues, with highest levels seen in adipose tissue, pancreas, and skeletal muscle (2).


Gene Aliases:

BP-1, EIF4EBP1, PHAS-I, MGC4316


Genbank Number:


References:


1. Pause, A. et al: Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5-prime-cap function. Nature371: 762-767, 1994.

2. Tsukiyama-Kohara, K. et al: Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2. Genomics38: 353-363, 1996.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~40 kDa



Product Datasheets



RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Cancer, Metabolic Disorder


RELATED PRODUCTS


  EIF4E Protein, E34-30G

  p70S6K, Active, R21-10H

  Anti-eIF4E, E34-63R

  4EBP1 Protein, E35-54BH


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox