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4EBP1 Protein

Recombinant full-length human 4EBP1 Protein was expressed in E. coli cells using an N-terminal His tag.
Catalog No. E35-54BH


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Catalog No. Pack Size Price (USD)
E35-54BH-50 50 ug $435
E35-54BH-20 20 ug $215
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Overview:

4EBP1 is a member of a family of translation repressor proteins that directly interact with eukaryotic translation initiation factor 4E (EIF4E). Interaction of 4EBP1 with EIF4E inhibits the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs thereby leading to repression of translation. Insulin treatment of adipose cells increases the phosphorylation of 4EBP1 and leads to reduced interaction of 4EBP1 with EIF4E (1). 4EBP1 is expressed in most tissues, with highest levels seen in adipose tissue, pancreas, and skeletal muscle (2).


Gene Aliases:

BP-1, EIF4EBP1, PHAS-I, MGC4316


Genbank Number:


References:


1. Pause, A. et al: Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5-prime-cap function. Nature 371: 762-767, 1994.

2. Tsukiyama-Kohara, K. et al: Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2. Genomics 38: 353-363, 1996.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~19 kDa



Product Datasheets



RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Cancer, Metabolic Disorder


RELATED PRODUCTS


  4EBP1 Protein, E35-54G

  4EBP1 Protein, E35-54H


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