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FRS3 Protein

Recombinant full-length human FRS3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. F80-30G


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Catalog No. Pack Size Price (USD)
F80-30G-50 50 ug $435
F80-30G-20 20 ug $215
F80-30G-BULK BULK Contact Us  


Overview:

FRS3 or fibroblast growth factor receptor substrate 3 is a peripheral plasma membrane protein that is a substrate for the fibroblast growth factor receptor. During FGF or NGF stimulation, FRS3 becomes tyrosine phosphorylated and then serves as a platform for the recruitment of multiple signaling proteins for activation of the Ras-MAP kinase signaling cascade (1). FRS3 is mainly expressed in fibroblast and myoblast cell lines and undergo robust tyrosine phosphorylation in response to several mitogenic ligands. Through interaction with Rho family of small GTPases, FRS3 has been implicated in the reorganization of the actin cytoskeleton and subsequent morphological changes in various cells (2).


Gene Aliases:

SNT2, FRS2B, FRS2beta, MGC17167


Genbank Number:


References:


1. Huang L, et al: SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation. Biochem Biophys Res Commun. 2004 Nov 19;324(3):1011-7.

2. Xu H, et al: Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins. J. Biol. Chem. 273: 17987-17990, 1998.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~87 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Cancer, ERK/MAPK Pathway



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