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PRKAR1B Protein

Recombinant full-length human PRKAR1B was expressed in Sf9 insect cells using a C-terminal His tag.
Catalog No. P59-30H


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Catalog No. Pack Size Price (USD)
P59-30H-50 50 ug $435
P59-30H-20 20 ug $215
P59-30H-BULK BULK Contact Us  


Overview:

PRKAR1B is the type I-beta regulatory subunit of cyclic AMP-dependent protein kinase A (PKA) which is an essential enzyme in the cAMP signaling pathway. PKA holoenzyme is composed of 2 regulatory and 2 catalytic subunits and dissociates from the regulatory subunits upon binding of cAMP. PKA controls many biochemical events in the cell including regulation of metabolism, ion transport, and gene transcription. PKA undergoes a dramatic conformational change upon complex formation with the catalytic subunit (1). PRKAR1B subunits can dimerize through an N-terminal motif and this dimerization is necessary for binding to PKA anchoring proteins (AKAPs) and targeting of PKA to its site of action.


Gene Aliases:

PRKAR1


Genbank Number:


References:


1. Gullingsrud J, et al. Dynamic binding of PKA regulatory subunit RI alpha.Structure, 2006 Jan. PMID 16407073.

2. Carlson, C R. et al: A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system. J Mol Biol. 2003 Mar 28;327(3):609-18.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~52 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, PKA/PKC Pathway


RELATED PRODUCTS


  PRKAR1A Protein, P57-30H

  PRKY Protein, P82-35G


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