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ATF2 Protein

Recombinant human ATF2 (1-254) was expressed in E.coli cells using a N-terminal GST tag.
Catalog No. A10-55G


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Catalog No. Pack Size Price (USD)
A10-55G-50 50 ug $435
A10-55G-20 20 ug $215
A10-55G-BULK BULK Contact Us  


Overview:

Activating transcription factor (ATF)-2, also designated CRE-BP1, is a member of the ATF/cyclic AMP-responsive element binding protein family of transcription factors. ATF2 has two unique characteristics: it mediates the adenovirus E1A-induced trans-activation and forms a heterodimer with c-Jun (1). ATF2 is a target of the JNK signal transduction pathway (2). ATF2 is phosphorylated by JNK on two closely spaced threonine residues within the NH2-terminal activation domain. The replacement of these phosphorylation sites with alanine inhibited the transcriptional activity of ATF2. Furthermore, p38 MAPK can also phosphorylate ATF2.


Gene Aliases:

HB16; CREB2; TREB7; CRE-BP1; MGC111558


Genbank Number:


References:


1. Nomura, N. et al: Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1.J Biol Chem. 1993 Feb 25;268(6):4259-66.

2. Gupta, S. et al: Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science. 1995 Jan 20;267(5196):389-93.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~55 kDa



Product Datasheets



RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway


RELATED PRODUCTS


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  Anti-ATF2, A10-63R

  p38 alpha, Active, M39-10BG


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