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PDE12 Protein

Recombinant full-length human PDE12 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P100-30G


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Catalog No. Pack Size Price (USD)
P100-30G-50 50 ug $435
P100-30G-20 20 ug $215
P100-30G-BULK BULK Contact Us  


Overview:

PDE12 is 2', 5'-phosphodiesterase 12 protein that belongs to the CCR4/nocturin family. PDE12 cleaves the 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates. Triphosphorylated oligoadenylates, which are referred to as 2-5A, modulates in the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs) (1). Suppression of PDE12 induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.


Gene Aliases:

2'-PDE


Genbank Number:


References:


1. Kubota K. et.al: "Identification of 2'-phosphodiesterase, which plays a role in the 2-5A system regulated by interferon." J. Biol. Chem. 279:37832-37841,2004.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~100 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cardiovascular Disease, Inflammation, Phosphodiesterases


RELATED PRODUCTS


  PDE3B, Active, P91-31BG

  PDE4C, Active, P92-31CG

  PDE9A, Active, P97-30G

  PDE5A, Active, P93-31G


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