Overview:

PDE12 is 2', 5'-phosphodiesterase 12 protein that belongs to the CCR4/nocturin family. PDE12 cleaves the 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates. Triphosphorylated oligoadenylates, which are referred to as 2-5A, modulates in the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs) (1). Suppression of PDE12 induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

Gene Aliases:

2'-PDE

Genbank Number:

NM_177966

References:

1. Kubota K. et.al: "Identification of 2'-phosphodiesterase, which plays a role in the 2-5A system regulated by interferon." J. Biol. Chem. 279:37832-37841,2004.