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PHLPP2 Protein

Recombinant human PHLPP2 (766-1043) was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. P72-21G


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Catalog No. Pack Size Price (USD)
P72-21G-50 50 ug $435
P72-21G-20 20 ug $215
P72-21G-BULK BULK Contact Us  


Overview:

PHLPP2 or PH domain and leucine rich repeat protein phosphatase 2 is the important regulators of Akt serine-threonine kinases and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 differentially regulated AKT signaling by selectively dephosphorylating the hydrophobic motifs of AKT2 or AKT3. PHLPP may act as a tumor suppressor in several types of cancer due to its ability to block growth factor-induced signaling in cancer cells.


Gene Aliases:

KIAA0931; PHLPPL


Genbank Number:


References:


1. Brognard, J. et.al: PHLPP and a second isoform, PHLPp2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Molec. Cell 25: 917-931, 2007


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~ 56 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Cancer, Phosphatases, PKA/PKC Pathway



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