PHLPP2 Protein
Recombinant human PHLPP2 (766-1043) was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. P72-21G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P72-21G-20 | 20 ug | $215 | |
| P72-21G-50 | 50 ug | $435 | |
| P72-21G-BULK | BULK | Contact Us |
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Recombinant human PHLPP2 (766-1043) was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. P72-21G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P72-21G-20 | 20 ug | $215 | |
| P72-21G-50 | 50 ug | $435 | |
| P72-21G-BULK | BULK | Contact Us |
Overview:
PHLPP2 or PH domain and leucine rich repeat protein phosphatase 2 is the important regulators of Akt serine-threonine kinases and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 differentially regulated AKT signaling by selectively dephosphorylating the hydrophobic motifs of AKT2 or AKT3. PHLPP may act as a tumor suppressor in several types of cancer due to its ability to block growth factor-induced signaling in cancer cells.
Gene Aliases:
KIAA0931; PHLPPL
Genbank Number:
References:
1. Brognard, J. et.al: PHLPP and a second isoform, PHLPp2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Molec. Cell 25: 917-931, 2007
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~ 56 kDa
There are no related publications available for this product.
AKT/PKB Pathway, Cancer, Phosphatases, PKA/PKC Pathway
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