Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates the inositol ring of phosphatidylinositol and related lipid products at the 3-prime position. PI3K p85 subunit which is the regulatory subunit of PI3K and consists of 2 closely related proteins, p85-alpha and p85-beta (1). The activation of PI3K signaling in influenza A virus-infected cells is important for efficient virus replication (2). PI3K signaling in T cells can lead to organ-specific autoimmunity and the class IA PI3K-deficient mice manifest the cardinal features of human primary Sjogren’s syndrome-like disease (3).
PIK3R2, P85B, p85-BETA
1. Otsu, M., et.al: Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60(c-src) complexes, and PI3-kinase. Cell 65: 91-104, 1991.
2. Hale, B. G. et.al: Influenza A virus NS1 protein binds p85-beta and activates phosphatidylinositol-3-kinase signaling. Proc. Nat. Acad. Sci. 103: 14194-14199, 2006.
3. Oak, J. S.,et.al: Sjogren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase. Proc. Nat. Acad. Sci. 103: 16882-16887, 2006.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
FU Rutaganira et al., Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ Journal of Medicinal Chemistry March 2016 10.1021/acs.jmedchem.5b01311
L Maasa Nancy et al., Generation and characterization of an analog-sensitive PERK allele Cancer Biology & Therapy May 2014 10.4161/cbt.29274
Furukawa S et al., PI3Kδ Inhibition Augments the Efficacy of Rapamycin in Suppressing Proliferation of Epstein?Barr Virus (EBV)+ B Cell Lymphomas American Journal of Transplantation July 2013 10.1111/ajt.12328
R Nehme et al., New in-capillary electrophoretic kinase assays to evaluate inhibitors of the PI3k/Akt/mTOR signaling pathway Analytical and Bioanalytical Chemistry May 2014 10.1007/s00216-014-7790-z
Vidugiriene Jolanta et al., Evaluating the Utility of a Bioluminescent ADP-Detecting Assay for Lipid Kinases ASSAY and Drug Development Technologies January 2010 10.1089/adt.2009.0223
AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling