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ENPP2 Protein

Recombinant human ENPP2 (36-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. E22-35G


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Catalog No. Pack Size Price (USD)
E22-35G-20 20 ug $215
E22-35G-50 50 ug $435
E22-35G-BULK BULK Contact Us  


Overview:

ENPP2 functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids which evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. It also may induce parturition (1). ENPP2 stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas (2).


Gene Aliases:

ATX, ATX-X, AUTOTAXIN, LysoPLD, NPP2, PD-IALPHA, SMG1


Genbank Number:


References:


1. Tokumura, A. et.al: Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase. J. Biol. Chem. 277: 39436-39442, 2002.

2. Murata, J. et.al: cDNA cloning of human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases. J. Biol. Chem. 269: 30479-30484, 1994.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~126 kDa



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cancer, Inflammation



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