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PDE6C Protein

Recombinant full-length human PDE6C was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P94-34CG


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Catalog No. Pack Size Price (USD)
P94-34CG-20 20 ug $215
P94-34CG-50 50 ug $435
P94-34CG-BULK BULK Contact Us  


Overview:

PDE6C or phosphodiesterase 6C, cGMP-specific, cone, alpha prime encodes the alpha-prime subunit of cone phosphodiesterase, which is composed of a homodimer of two alpha-prime subunits and 3 smaller proteins of 11, 13, and 15 kDa. PDE6C protein consists of 22 exons spanning approximately 48 kb of genomic DNA. The intron-exon structure of human PDE6C is very similar to that of rod PDE6B (1). A homologous genetic basis of the murine cpfl1 mutant and human achromatopsia linked to mutations in the PDE6C gene and mutations in PDE6C are associated with cone dystrophy type 4 (COD4) (2).


Gene Aliases:

PDEA2


Genbank Number:


References:


1. Chang, B. et.al: A homologous genetic basis of the murine cpfl1 mutant and human achromatopsia linked to mutations in the PDE6C gene. Proc. Nat. Acad. Sci. 106: 19581-19586, 2009.

2. Piriev, N. I. et.al: Gene structure and amino acid sequence of the human cone photoreceptor cGMP-phosphodiesterase alpha-prime subunit (PDEA2) and its chromosomal localization to 10q24. Genomics 28: 429-435, 1995.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~125 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cardiovascular Disease, Inflammation, Phosphodiesterases


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