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PI3K (p65 alpha) Protein

Recombinant human PI3K (p65 alpha) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag. This protein is an N-terminus fragment (1-571) of full-length PIK3R1 (p85 alpha).
Catalog No. P31-31H


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Catalog No. Pack Size Price (USD)
P31-31H-20 20 ug $215
P31-31H-50 50 ug $435
P31-31H-BULK BULK Contact Us  


Overview:

PIK3R1 is a Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position which comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kDand it encodes the 85 kD regulatory subunit. PIK3R1 protein associates with activated growth factor receptors. p85-alpha modulates the interaction between PI3 kinase and platelet-derived growth factor receptor (1). PI3K plays an essential role in the development and induction of mast cells in normal and pathogenic immune responses (2).Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance.


Gene Aliases:

PIK3R1, GRB1, p85-ALPHA


Genbank Number:


References:


1. Skolnik, E. Y. et.al: Cloning of PI3-kinase associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell 65: 83-90, 1991.

2. Fukao, T. et.al: Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice. Nature Immun. 3: 295-304, 2002.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~67 kDa



Product Datasheets



RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling


RELATED PRODUCTS


  PI3K (p55 gamma) Protein, P31-30CH

  PI3K (p85 alpha) Protein, P31-30H

  PI3K (p85 beta) Protein, P31-30BH


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