Overview:

PIK3R1 is a Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position which comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kDand it encodes the 85 kD regulatory subunit. PIK3R1 protein associates with activated growth factor receptors. p85-alpha modulates the interaction between PI3 kinase and platelet-derived growth factor receptor (1). PI3K plays an essential role in the development and induction of mast cells in normal and pathogenic immune responses (2).Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance.

Gene Aliases:

PIK3R1, GRB1, p85-ALPHA

Genbank Number:

NM_181523

References:

1. Skolnik, E. Y. et.al: Cloning of PI3-kinase associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell 65: 83-90, 1991.

2. Fukao, T. et.al: Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice. Nature Immun. 3: 295-304, 2002.