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NPM1 Protein

Full-length recombinant human NPM1 protein was expressed in E.coli cells using an N-terminal His tag.
Catalog No. N50-30H


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Catalog No. Pack Size Price (USD)
N50-30H-20 20 ug $160
N50-30H-50 50 ug $336
N50-30H-BULK BULK Contact Us  


Overview:

NPM1 or nucleophosmin (nucleolar phosphoprotein B23, numatrin) is a ubiquitously expressed nucleolar protein that shuttles between the nucleus and cytoplasm which is implicated in multiple functions, including ribosomal protein assembly and transport, control of centrosome duplication, and regulation of the tumor suppressor ARF NPM1 mutations that relocalize NPM1 from the nucleus into the cytoplasm are associated with development of acute myeloid leukemia (AML) (1). NPM1 is a target of CDK2/cyclin E in the initiation of centrosome duplication (2). NPM1 is involved in several processes including regulation of the ARF/p53 pathway. NPM1-ALK acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression.


Gene Aliases:

Nucleophosmin; B23; MGC104254; NPM


Genbank Number:


References:


1. Garzon, R.et.al: Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. Proc. Nat. Acad. Sci. 105: 3945-3950, 2008.

2. Okuda, M..et.al: Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell 103: 127-140, 2000.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~40 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cell Cycle



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