Overview:

NFKB2 is a part of the NFKB complex that is present in various cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and disease states. NFKB protein is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products (1). Inappropriate activation of NFKB has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS (2). Overexpression of NFKB2 protects androgen sensitive LNCaP cells from apoptotic cell death and cell cycle arrest induced by androgen-deprivation.

Gene Aliases:

NFKB2-p52, NFKB2-p100, LYT10, LYT-10

Genbank Number:

NM_002502

References:

1. Zhu, M. et al: NF-kappa-B2 is required for the establishment of central tolerance through an Aire-dependent pathway. J. Clin. Invest. 116: 2964-2971, 2006.

2. Tucker, E. et al: A novel mutation in the Nfkb2 gene generates an NF-kappa-B2 'super repressor' J. Immun. 179: 7514-7522, 2007.