Overview:

HtrA (also designated as DegP) is a trypsin-like serine protease which contains PDZ domain and involves in heat-shock response, chaperone function, and apoptosis (1). Analysis of strains with the htrA (S234A) catalytic site mutation showed that the proteolytic activity of HtrA selectively repressed competence when translational fidelity was high but not when accuracy was low (3).

Gene Aliases:

DegP, DegP/HtrA

Genbank Number:

B8ZQD0

References:

1. Ge X. et.al: DegP primarily functions as a protease for the biogenesis of beta-barrel outer membrane proteins in the Gram-negative bacterium Escherichia coli. FEBS J. 2013 Dec 26. doi: 10.1111/febs.12701.

2. Stevens KE. et.al: Competence in Streptococcus pneumoniae is regulated by the rate of ribosomal decoding errors. MBio. 2011 Sep 20;2(5). pii: e00071-11.