Overview:

PDE8A is a member of the phosphodiesterase family of proteins that play a critical role in regulating intracellular levels of cAMP and cGMP. PDE8A is a high-affinity cAMP-specific PDE expressed in a variety of tissues such as ovary and testis. PDE8A plays an important role in many biological processes, including T-cell activation, testosterone production, adrenocortical hyperplasia, and thyroid function. Targeted mutation in the PDE8A gene in Leydig cells show sensitivity in the action of LH in terms of testosterone production (1). PDE8A, through its PAS domain, can bind with IkappaB proteins in a region containing their ankyrin repeats. The association of PDE8A with IkappaB greatly enhanced the enzyme activity this enzyme (2).

Genbank Number:

NM_002605

References:

1. Chen C, et al: PDE8A genetic variation, polycystic ovary syndrome and androgen levels in women. Mol Hum Reprod. 2009 Aug;15(8):459-69.
2. Wu P, et al: Per-Arnt-Sim domain-dependent association of cAMP-phosphodiesterase 8A1 with IkappaB proteins. Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17634-9.